Although Guadalupe didn't incorporate until 1975, our history dates back to 1907.  Guadalupe is home to three cultures – with one of those cultures being the Yaqui Indians. The Yaqui Indians have endured many turbulent times beginning with wars fought against the Spanish and Mexicans. The Yaquis were trying to protect the land that they lived on near the Yaqui River in Sonora, Mexico. When Porforio Diaz defeated them, the Yaquis were sent down to the jungles of Yucatan. But during the Mexican Revolution, the Yaquis joined up with Pancho Villa. When Villa's army was defeated, the Yaquis headed to the United States for safety. Many of the Yaquis came up to the Salt River Valley to work on the construction of canals in the area. A community sprung up here – where we became Guadalupe.

Over the years many Hispanic families have also located in Guadalupe, and it has becoming a stopping point for Mexican immigrant workers. When the Yaqui people fled to Arizona. Anglos here were sympathetic to their plight as refugees and Yaquis were able to find a home in the Salt River Valley's agricultural economy. Catholic and Presbyterian missionaries also supported the community and helped secure land for a legal Town site in 1914. Residents voted to incorporate the town in 1975.